Alrighty I'll give you some random knowledge I know to you because yeah.
Okay so I recommend using your stylus (if you dont have one or you lost yours use a led pencil without led). You could always use your finger, of course, but I find a pencil like thing on my screen better than a whole finger covering up my page.
I do suggest to use the layers they are there for a reason! I sometimes sketch my drawing before the actual line art, so the layers really do help me!
Same goes with the brushes, if you're filling in something big use a bigger brush. For details use a smaller brush.
The colors are actually really hard to make but they have simple 3 colours so when you put for example, blue and red together it'll make purple! Or you could always just use black n' white.
DON'T PUT YOUR HAND ON THE SCREEN WHILE DRAWING IT WILL CREATE A LINE It really makes me angry while drawing and my hand accidentally touches the screen, please don't do that.
These were all at the top of my head. If you have any tips or tricks comment em!