Isaac Clarke. He battled through an entire ship of Necromorphs, let alone a space station. He suffered from dementia and multiple injuries, but he still prevailed.
Garrus Vakarian, obv. He can headshot with ridiculous accuracy, he has a futuristic monocle, and he can survive a missle to the face and still be awesome.
Cloud from FF7 he carries a huge sword that can also break into many little ones. His materia allows him to do pretty much everything and his hair defies gravity...That's winning..